His appearance is generally quite average, yet distinct. Both his 17-18 year old and 27-28 year old form have short dirty blond hair which is worn in no particular style and allowed to simply fall across his forhead in a distinctive fringe in the middle, with parts at either side, and sharp pale yellow eyes. Pre-ReLIFE, his build is more robust, with broad shoulders not unlike Kaizaki, and a defined face. Post-ReLIFE, while his features remain the same, his build is significantly slimmer and his face is less defined.
Ryo takes his job as Arata's supporter very seriously, even to the point of intervening in his ReLIFE to help him develop throughout it positively, despite this being against the rules of the ReLIFE program. Ryo is haunted by a past failure involving the subject before Arata, Subject 001, and this affects his view of himself and his job significantly. However, it seems that by watching Arata's ReLIFE, he is healing from his past failures and trauma, much like Arata is healing from his own. Ryo enjoys teasing people, and Arata often refers to him as a sadist, a title which he has taken as a compliment in the past. Despite this, Ryo does in fact care a great deal about Arata, and wishes for him to recover from his past through a wonderful ReLIFE, such that he will overstep his boundaries as an observer to steer Arata in what he feels is the right direction.
Yoake met Hishiro as she came out of a failed interview and informed her about the ReLIFE Project. He was then assigned as the supervisor for Kanto region's first ReLIFE Experiment, Hishiro Chizuru. He was expected to make Hishiro improve her interpersonal skills.He was also suggested into entering into a romantic relationship with her in the end to make her experiment a success. He was then put in the same class as Hishiro of the second year in Aoba High School.
Hishiro however made no effort to get to know the people in her class. Ryo was criticized of not lending enough support. He then tells Hishiro of the expectations and asks her to help out a bullied student in their class. This however made the bullying even worse due to Hishiro's clumsiness in handling the situation. The bullied student asked Hishiro not to interfere anymore and Hishiro totally avoided human contact. Ryo was then criticized for interfering too much with the experiment.
Month after month, there was no change in Hishiro's interpersonal relationships though she excelled in her studies. Ryo was continually criticized as either not providing enough support or interfering too much. Ryo felt the experiment only increased Hishiro's loneliness and tried to provide support,only to be rejected by her.
He was continually pressured into bringing better results by his superiors with Onoya being the only person who was supportive of him. After the latest meeting, Hishiro's ReLife was then considered a failure because there was no improvement.
Onoya then asks him to come with her to check out the new subjects. Onoya then praises him saying that Yoake is amazing as she would have gone crazy because of the tremendous work pressure. With all his work and mental strain taking a toll on him, he faints and falls down on Onoya.
An Onoya - An is actually a co-worker of Ryo Yoake at the company of ReLIFE. She personally reveals to Arata Kaizaki that she was originally his supporter for the ReLIFE experiment. She and Ryo have a Senpai-Kouhai relationship and she is constantly being scolded by Ryo for doing unnecessary actions.
- "We're all old enough to know better than to toy with the hearts of children."